Medicare drug plans may limit coverage of quadruple drug therapy for heart failure with reduced ejection fraction (HFrEF) through cost sharing, resulting in out-of-pocket (OOP) costs considerably higher than generic regimens and potentially unaffordable for many Medicare patients, according to a study published in JACC.

Happy heart syndrome is a rare type of takotsubo syndrome (TTS) and it has a higher prevalence of male patients and atypical, nonapical ballooning, compared with the more commonly known broken heart syndrome that is associated with negative emotional stressors, according to a study published in JACC: Heart Failure.

A retrospective study investigating the safety and efficacy of the PASCAL and PASCAL Ace System in treating tricuspid regurgitation (TR), published in JACC: Cardiovascular Interventions, found the leaflet repair system has "high technical and procedural success rates with efficient TR reduction." The study also noted significant clinical and echocardiographic improvement during follow-up.