Among individuals without significant cardiovascular morbidity younger than 50 years, the use of cannabis is linked to adverse cardiovascular events, including a sixfold higher risk of a myocardial infarction (MI), fourfold increase risk of ischemic stroke, twofold increased risk of heart failure (HF) and threefold increased risk of cardiovascular death, MI or stroke, according to a brief report published in JACC: Advances and presented at ACC.25 in Chicago. The findings suggest cannabis as a novel and underrecognized risk factor for cardiovascular disease.

Patients with severe aortic stenosis who were treated with either TAVR or surgery had comparable rates of all-cause mortality or disabling stroke at five years, according to research presented during a Late-Breaking Clinical Trial session at ACC.25 and simultaneously published in JACC. Valve durability and performance were also excellent in both groups.

Implantation of an intra-aortic balloon pump (IABP) did not improve 60-day survival or bridge to heart replacement (HRT) therapies in patients with heart failure-cardiogenic shock (HF-CS) compared to standard care, according to a study presented during a Featured Clinical Research session at ACC.25 i Chicago and simultaneously published in JACC. The trial was stopped by the Data Safety and Monitoring Board at the prespecified interim analysis due to futility.

Among young athletes, while overall survival after a sudden cardiac arrest (SCA) is improving, the likelihood of survival varies by race, and SCA is more likely to occur during practice than games, according to a study presented at ACC.25 and simultaneously published in JACC.