Journal Wrap | TAVR vs. Surgery at 7 Years; DOACs vs. DAPT Post LAAC
The hottest research from various peer-reviewed journals – handpicked weekly by the ACC.
PARTNER 3: TAVR vs. Surgery in Low-Risk Patients at 7 Years
Among low-risk patients with severe, symptomatic aortic stenosis who underwent either TAVR or surgery, the incidence of death, stroke or rehospitalization at seven years was similar across both groups, based on the newest findings from the PARTNER 3 trial. The results, presented at TCT 2025 and simultaneously published in NEJM, also appeared to show similar rates of valve durability and patient-reported outcomes.
PROMISE and iMODERN Trials Offer Fresh Insights Into MINOCA and STEMI Management
Late-breaking science presented at TCT 2025 addressed immediate PCI guided by instantaneous wave-free ratio (iFR) vs. deferred PCI of nonculprit lesions in acute STEMI patients, as well as management of patients with myocardial infarction with nonobstructive coronary arteries (MINOCA).
ANDES: DOACs vs. DAPT After LAAC in Patients With Nonvalvular AFib
The use of direct oral anticoagulants (DOACs) following transcatheter left atrial appendage closure (LAAC) in patients with nonvalvular atrial fibrillation (AFib) was not superior to DAPT in preventing device-related thrombosis (DRT), based on findings from the ANDES trial presented at TCT 2025 and simultaneously published in Circulation. However, researchers did note DOACs use was associated with an improved safety profile.
ENCIRCLE: Percutaneous Transseptal TMVR System in Patients Not Eligible for Surgery or TEER
Percutaneous transseptal mitral valve replacement (TMVR) using the SAPIEN M3 system effectively reduced mitral regurgitation with low rates of complications and mortality in patients with symptomatic, moderate-to-severe mitral regurgitation (MR) who were not candidates for conventional surgery or transcatheter edge-to-edge repair (TEER).
TCT 2025 Hub
Visit the Hub at ACC.org/TCT2025 for all the coverage from the ACC.org Editorial team, including news stories, trial summaries, journal scans, video roundups and more.
Clinical Topics: Acute Coronary Syndromes, Anticoagulation Management, Arrhythmias and Clinical EP, Invasive Cardiovascular Angiography and Intervention, Valvular Heart Disease, Anticoagulation Management and ACS, Implantable Devices, SCD/Ventricular Arrhythmias, Atrial Fibrillation/Supraventricular Arrhythmias, Interventions and ACS, Interventions and Imaging, Interventions and Structural Heart Disease, Angiography, Nuclear Imaging
Keywords: Cardiology Magazine, ACC Publications, Transcatheter Cardiovascular Therapeutics, TCT25, Heart Valve Diseases, Acute Coronary Syndrome, Arrhythmias, Cardiac, Anticoagulants, Angiography
